Gastrointestinal Mucosal Repair and Experimental Therapeutics

C. H. Cho, J. Y. Wang, "Gastrointestinal Mucosal Repair and Experimental Therapeutics"
English | ISBN: 3805573820 | edition 2002 | PDF | 252 pages | 3,1 mb
Over the last decade, considerable progress has been made in
understanding cellular and molecular mechanisms involved in
gastrointestinal mucosal injury and repair. These findings provide the
basis to identify the etiology and pathogenesis of various gut mucosal
injury-related diseases and to develop new therapeutic approaches. The
publication at hand is divided into three sections: Epithelial
restitution, mucosal repair and ulcer healing, and experimental
therapeutics.

The first part highlights the early rapid mucosal restitution, focussing
on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+
signaling, polyamines, and the protein kinase C / DAG pathways. The next
section deals with aspects of chronic mucosal healing, concentrating on
the roles of primary response gene expression, angiogenesis and
angiogenic growth factors, platelets, and the mechanisms of cell renewal
after injury in special circumstances. The last part explores new
therapeutic approaches.




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